Science: 125
Science magazine, one of the top journals in science is celebrating their 125th anniversary.
Rather than a “top papers” rehash of the past 125 years of discovery (which would be pretty impressive), the journal has posted a list of the “top 125 questions: what we don’t know.” 125th Anniversary Issue: Science Online Special Feature (free online access)
There are some pretty impressive questions listed. Anyone need any research proposal ideas? 
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Geoff — 4 years, 8 months ago.
I thought I should include a list of some of the questions I think are particularly interesting…
How far can we push chemical self-assembly?
More questions… (lots and lots of good ones actually, but several are more “chemistry-related”)
Is it possible to create magnetic semiconductors that work at room temperature?
What is the pairing mechanism behind high-temperature superconductivity?
Can we develop a general theory of the dynamics of turbulent flows and the motion of granular materials?
Are there stable high-atomic-number elements?
What is the structure of water?
What is the nature of the glassy state?
Are there limits to rational chemical synthesis?
What is the ultimate efficiency of photovoltaic [solar] cells?
What is the origin of homochirality in nature?
Can we predict how proteins will fold?
Yes, that’s what’s amazing about science. We still don’t know enough about glasses or the exact structure of water.